A peer-reviewed University of Cambridge study published Wednesday in the scientific journal Nature has revealed the Nobel Prize-winning technique that paved the way for synthetic messenger ribonucleic acid vaccines is far from flawless.
To trick the body into allowing cellular interventions by synthetic mRNA-based therapeutics, scientists discovered they first had to make chemical modifications to the building blocks of the mRNA. Researchers indicated this week that encounters with repeat base modifications often lead to cellular miscommunications, which ultimately trigger immune flare-ups in vaccine recipients.
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